The Bath Music Festival Another idea for getting new recruits is to ask your best customers. Do you have one of those great customers who spend $50 or more every campaign? Do you have a customer that is a great helper that brings you extra orders every campaign? These kind of customers are the best prospects for new recruits! By this stage you should have decided on the subject/s that your event is going to cover. Will you be personally talking about your expertise? Exactly what portion of your expertise will you assign the time to? Some families will head to Kings Dominion for the Bachata festival wristbands on Sept. 1 for a day filled with live music and rides. Others will be entertained at Busch Gardens or Water Country, USA. SET THE DATE: The date of your event will depend on a couple of things. If it is a birthday or anniversary event wristbands then you are controlled by the date. If it is just a party the date may be controlled by the locations availability. If the event is at your home then you are in control. Pick what ever date you want. I have even gone as far as check with some guests a couple weeks in advance to make sure they are available on a certain date. I really like success! We can all picture the scene - arriving at a camp site to find that the toilet facilities look like something out of a horror film. Disgusting and clearly not to the standards of hygiene that we would set for ourselves sport wristbands there is little that could be less appealing. This is about the big picture of creating a healthy, happy lifestyle here. It"s not always going to look exactly the way we think it should. As long as it"s healthy overall, then cool it with the stress and guilt. That kind of thinking will create its own negative health consequences. These events are fun and exciting. I personally will be going to Delta Fair and Music Festival so that I can take my daughter to enjoy all of the rides and see all of the vendors, I am a sucker for good crafts and end up spending a bundle. On that note, I hope this will guide you in some ideas for the weekend. Labor Day signifies the end of summer and there is no need to let it go to waste.

[Photo/VCG]

WASHINGTON - Chinese scientists found that a popular gene-editing tool may lead to wide off-target mutations, warning of serious clinical safety risks of the gene-editing technique.

The study published on Thursday in the journal Science showed that a type of base editor used to convert DNA base pairs caused high numbers of off-target mutations in the genomes of mouse embryos.

CRSIPR-Cas9 is a revolutionary genome editing tool developed in recent years that enabled researchers to edit parts of the genome by removing, adding or altering sections of the DNA sequence.

It is a simple, versatile and precise method of genetic manipulation but it may introduce errors outside of the target locations, causing concerns of leading to cancers if being carelessly applied clinically.

Scientists led by Yang Hui from the Institute of Neuroscience of Chinese Academy of Sciences created a new off-target testing method called GOTI to test BE3, a single-base gene editor based on CRSIPR-Cas9.

They found the off-target mutations partially took place at cancer-inhibiting genes, previously believed highly unlikely to take place, demonstrating that the technique is inappropriate to be used clinically.

Yang told Xinhua that off-target effects are the largest source of risks for gene-editing technology, but no method could accurately predict those risks previously.

Many genetic diseases are caused by single-base mutations, according to the researchers.

"The single-base gene-editing method was believed to be safe but the new testing tool showed the contrary, so we should make clinical standards as soon as possible to ensure the safety of gene-editing technique," said Yang.

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